Allopurinol

Brand Names of Allopurinol: Zyloprim, Aloprim, Lopurin, Purinol, Zyloric.

What is Allopurinol?

  • Allopurinol effectively treats gout, a type of arthritis caused by excess uric acid in joints.

  • It falls under the category of xanthine oxidase inhibitors.

How Does it Work and Why is it Important to Take?

  • Allopurinol reduces uric acid production, preventing crystal formation which cause the painful gout attacks.

  • Consistent intake is vital to lower uric acid levels and avoid joint inflammation.

The Dose of The Medication

  • Typically starts with a low dose, adjusting based on uric acid levels.

  • Maximum daily dose is 900mg.

How and When to Take It

  • Usually taken once daily; higher doses split into two.

  • Best taken with food; if fluid is advised, aim for 2-3 litres daily.

  • Consistency is key—try taking it at the same time each day.

What to Expect

  • Reduction in uric acid takes a few weeks.

  • Initial gout attacks may occur; clinicians may prescribe an anti-inflammatory drug alongside Allopurinol

  • Don't stop taking Allopurinol during a gout attack, it will make the attack worse

What to Do if You Miss a Dose

  • If you forget a dose, take it when you remember.

  • If it's close to your next scheduled dose, skip the missed one—never double up.

Possible Side Effects

  • Nausea and vomiting

Management of Side Effects

  • Click here for common side effects and how to manage them.

  • Some side effects improve as your body adjusts.

  • If severe, persistent or bothersome side effects occur, consult your GP, local pharmacy, or NHS 111.

Common Interactions

  • Inform your clinician about all medications, including over-the-counter and herbal supplements.

Special Warnings

  • Your diet affects gout, including alcohol intake.

  • If a rash develops, stop Allopurinol and see your GP clinician or call NHS 111

Monitoring Your Progress

  • Regular check-ups with your GP are essential to monitor uric acid levels and potential side effects.

Where to Find More Information and Who to Contact

  • Refer to the patient information leaflet and the NHS website for more details.

  • If you have questions or experience unusual symptoms, contact your GP clinician, local pharmacy, or NHS 111.