Mirtazapine
What is Mirtazapine?
Mirtazapine is commonly used to treat mental health conditions such as depression, obsessive-compulsive disorder (OCD), and anxiety.
How Does it Work and Why is it Important to Take?
Mirtazapine works by increasing the levels of serotonin and noradrenaline in the brain, which can influence your mood.
Taking Mirtazapine is important for fostering a positive mental state and overall well-being.
The Dose of The Medication
The usual starting dose of Mirtazapine is 15mg to 30mg per day, with a maximum daily dose of 45mg.
In some cases, clinicians may recommend splitting the dose to take it twice a day.
How and When to Take It
Mirtazapine is typically taken once a day, usually at bedtime as it can cause drowsiness.
If prescribed twice a day, take the smaller dose in the morning and the higher dose at bedtime.
What to Expect
Immediate effects may not be noticeable; it takes patience.
Improvement may take a week, with full effects in 4-6 weeks.
What to Do if You Miss a Dose
If you miss a dose of once-daily Mirtazapine, skip it and take the next dose at your usual time—never double up.
For twice-daily dosing, adjust as follows:
Missed morning dose: Take it at bedtime with the evening dose.
Missed evening dose: Skip it, and resume normal dosing the next day.
Possible Side Effects
Increased appetite and weight gain
Nausea and vomiting
Headaches
Dry mouth
Feeling sleepy
Diarrhoea
Constipation
Management of Side Effects
Click here for common side effects and how to manage them.
Mirtazapine can increase hunger, so focus on healthy eating and exercise.
Some side effects improve as your body adjusts.
If severe, persistent or bothersome side effects occur, consult your GP, local pharmacy, or NHS 111.
Common Interactions
Inform your clinician about all medications, including over-the-counter and herbal supplements.
Avoid St. John’s Wort, a herbal remedy for depression.
Special Warnings
Seek immediate medical attention if your mood worsens or in emergencies.
Limit alcohol consumption to avoid increased drowsiness.
Do not abruptly stop treatment to avoid withdrawal symptoms.
Monitoring Your Progress
Regular check-ups with your GP clinician are important to monitor your response to the medication and assess potential side effects.
Where to Find More Information and Who to Contact
Refer to the patient information leaflet and the NHS website for more details.
If you have questions or experience unusual symptoms, contact your GP clinician, local pharmacy, or NHS 111.